Mixed Consumption

Combining two or more substances in a short period of time puts a heavy strain on both body and mind. The effects of combining two or more substances are difficult to predict and generally do not correspond to the sum of the effects of either individual substance (1 + 1 ≠ 2) . Depending on the substance, the respective effects may be potentiated or intensified (e.g., extreme dopamine concentrations), or they may influence the body and mind in different ways (stimulation versus sedation). Both are stressful for the body. The risk of unpleasant, even medical, incidents or severe hangovers increases with mixing substances. If you still choose to mix substances, avoid particularly risky combinations and observe the following safer use guidelines:

Make sure you first learn about the effects of the substances individually, without any interaction with other substances.
At least wait until the full effects of one substance have worn off before consuming the next.
Keep in mind that different substances take different amounts of time to reach their maximum effect.
Due to the high strain on the liver and kidneys, drink plenty of water (500 ml/hour). Avoid alcohol.
Alcohol generally alters the effects of other psychoactive substances.
Using uppers to delay the comedown intensifies the hangover and increases the risk of unpleasant after-effects. Downers used to come down prolong the hangover and usually have a high potential for addiction.
Friends or acquaintances who are present should know what and how much you have consumed/mixed.
If you are taking medication, inform yourself about possible risky interactions with drugs (impairment of effectiveness, serious complications!).