A sample labeled as 4-FA (4-fluoroamphetamine) did not contain 4-FA, but rather 4F-MPH (4-fluoromethylphenidate), caffeine, and a small amount of MDMA (2.0%).

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4F-MPH is a synthetic stimulant from the phenidate class and structurally related to methylphenidate (Ritalin), which is used to treat ADHD and narcolepsy. It primarily works by increasing the concentration of dopamine and norepinephrine in the brain, resulting in a stimulating, concentration-enhancing, and energizing effect.

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Although both substances have stimulant properties, there are significant differences in their effects, dosage, and duration of action, which can lead to an increased risk of overdose.

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4F-MPH is a synthetic stimulant from the phenidate class and structurally related to methylphenidate (Ritalin), which is used to treat ADHD and narcolepsy. It works primarily by increasing the concentration of dopamine and norepinephrine in the brain, resulting in a stimulating, concentration-enhancing, and drive-enhancing effect.

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Although both substances have stimulant properties, there are significant differences in their effects, dosage, and duration of action, which can lead to an increased risk of overdose.

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4F-MPH primarily enhances focus and performance, with a faster onset and shorter duration of action (approximately 4–6 hours vs. 4-FA: 4–8 hours).

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4-FA is administered in significantly higher doses—an average dose is around 100–130 mg orally—while 5–15 mg nasally or orally is considered an average dose of 4F-MPH. Applying a typical 4-FA dose to a sample of 4F-MPH can lead to unexpectedly strong and harmful effects.

Higher doses of 4F-MPH can cause seizures, cardiac arrhythmias, insomnia, nervousness, headaches, and confusion.

The simultaneous use of multiple pharmacologically active substances poses an additional health risk. Combining 4F-MPH with caffeine and MDMA places increased strain on the cardiovascular system. Since the MDMA in this sample is present only in very small amounts, risky interactions with MDMA are unlikely.

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With powders and crystalline samples, mislabeling and contamination are common; therefore, it is essential to have them tested at a drug checking facility before consumption!